Lewis led the Sooners with 15 tackles, two of which went for loss, in the 58-35 victory. He also intercepted two passes and chalked up 55 yards in returns.
Lewis got his first pick on KSU’s opening possession and returned it 27 yards to set up OU’s first score. The Sooners never trailed in the game.
The San Antonio, Texas, native is OU's leading tackler this season with 84, the second-highest total ever by a Sooner freshman linebacker. Brian Bosworth holds that mark with 133 in 1984.
Lewis tied Bosworth's single-game freshman record when he recorded 19 tackles against Texas.
Other Sooners to capture Big 12 Defensive Player of the Week honors this season were Keenan Clayton against Baylor and Lendy Holmes against Kansas.
The Big 12 handed out its other awards this week to Texas Tech's Graham Harrell (offense) and Matt Williams (special teams).