OU stranded 11 runners on base, including the bases loaded in the first and at least one in each inning outside of the fourth, fifth and ninth.
"Well, overall I thought we had missed opportunities early on," said OU head coach Sunny Golloway. "We had a chance to bunt the ball first and second, no outs. We didn't get him bunted up. We didn't end up scoring. [If] we bunt him up, we get him scored. We end up having the bases loaded. You know, we had bases loaded there with [Garrett] Carey up and we pop it up to the infield with one out.
"So, we gotta score first of all when you got bases loaded with one out. We don't. And then we've gotta be able to bunt the guys up first and second."
In the meantime, the Waves had already took an early 2-0 lead in the top of the first on catcher Nate Johnson's two-run double.
The Sooners chipped into it in the third, as first baseman Matt Oberste—he finished a double short of the cycle—ripped a triple to center and scored on Carey's sacrifice fly.
They tied it when Oberste smashed a solo shot over the left field wall in the bottom of the fifth.
"I was trying to see something up and, you know, he threw me a low fastball," Oberste said. "He hung a slider in there, just got around on it."
But OU could never get over the top.
Pepperdine retook the lead in the sixth after left fielder Chris Amezquita singled and raced home moments later on an RBI groundout.
They plated four in the ninth to put it away, three of which came on a massive bomb by third baseman Austin Davidson off Sooner reliever Jacob Fisher.
Sooner starter Jonathan Gray was tagged with the loss despite delivering a quality start which featured three earned runs on five hits and two walks to his seven strikeouts.
Pepperdine's Corey Miller earned the win after tossing 6 1/3 innings of two-run ball, giving up eight hits and a walk and fanning a pair.
Oberste finished 3-for-4 with an RBI and two runs scored, while Davidson and Johnson each had multi-RBI days for the Waves.
The two conclude the series with the rubber match at 1 p.m. Sunday.
"We've got a lot of freshmen in the lineup and we're gonna start Adam Choplick, who's a freshman," Golloway said. "And it'll be interesting to see how we respond, we come back."