Guard Steven Pledger, as he's done so many times throughout his career, paced the Sooners with his sharp shooting, drilling 8-of-15 shots and six threes for a game-high 23.
Forward Romero Osby didn't finish far behind with his 21 points.
For Tech, three finished with that feat, including guard Josh Gray, who led the way with a game-high 26.
OU led it basically from the get-go, rattling off the game's first seven points.
But Tech used a 9-0 run to come back and grab its first lead of the game at 15-14 just more than eight minutes in.
OU eventually seized a 32-27 halftime advantage in what was a tightly contested first half.
Midway through the second half, the Sooners finally built that to a double-digit lead, but Tech wouldn't go away for a bit until they iced it down the stretch with a 10-2 run.
The Sooners (17-8, 8-5 Big 12) get back to action with a chance to earn their first .500 or better conference season since 2008-09 when they play host to Baylor at 4 p.m. Saturday inside Lloyd Noble Center.