Her explosion featured a two-homer, six-RBI onslaught in game two against Oregon State, in which she belted out a grand slam in an 11-run fourth inning.
"She's such a smart hitter," said OU head coach Patty Gasso. "I think pitchers get really uncomfortable because I don't know what you can call that she can't hit. She's disciplined, smart, calculated, powerful and quick. Everything you would want in an athlete, she's it."
That allowed the Sooners to take control of a game they trailed 2-0 after the top of the first inning.
Chamberlain's first homer of the contest in the bottom half cut that deficit to 2-1 at the time and it took the lead for good in the following inning on a costly Beavers error.
Michelle Gascoigne got the win after fanning nine in the five-inning shutout.
In the first game, along with Chamberlain's homer, it was all about the Keilani Ricketts show as she's displayed so many times.
Last season's USA Softball Player of the Year struck out 14 en route to managing a no-hitter in the season opener over No. 21 Stanford.
"I think I came in really confident and relaxed because we had already gotten ahead with a huge lead so I didn't have pressure on me, too much," Ricketts said.
That lead came when the Sooners smashed back-to-back-to-back homers in the top of the first.
Catcher Jessica Shults slammed the first, then Ricketts, and designated player Shelby Pendley capped off the perfect three hitter stretch.
OU milked their at-the-time 5-0 lead to a 6-0 win.
The Sooners get back to action Saturday with another doubleheader, including the 10 a.m. opener against No. 5 Oregon.