"It was a pretty good game today," said OU head coach Bob Stoops. "I was pleased overall with our players."
The victory moves OU to 2-0 on the young season heading into its first bye week.
It didn't take long for Williams, a week removed from his first career touchdown as a Sooner, to pick up his first career touchdown at Oklahoma Memorial Stadium.
That was a 3-yard scamper at the 7:05 mark of the first quarter.
But he wasn't even close to done there.
He found pay dirt again on a 4-yard touchdown run just a couple minutes later after Justin Brown took a punt return back to the 4 and it was 14-0 OU midway through the first.
"Damien's a strong, powerful guy with excellent speed," Stoops said. "So, it's exciting to see him play the way he is."
FAMU prevented the shutout when place kicker Chase Varnadore booted through a 41-yarder early in the second quarter.
That's when OU got back on the board again, yet another time behind Williams' legs.
He flurried 15 yards, and OU leapt out to a 21-3 lead.
"I felt we all played well as a team," Williams said. "My line blocked well, they were ready for me, so I felt like everything went as planned."
Moments later, the Sooners scored for the first time through the air.
Quarterback Landry Jones, who threw for 211 yards and a pair of touchdowns in the first half, found wide receiver Kenny Stills for their second hookup of the season, a 16-yard connection to make it 28-3.
"That is huge," Jones said about Stills' ability to separate from the defenders. "He did a great job working the middle of the field. He did a great job of blocking, too."
FAMU responded quickly thereafter with its lone touchdown of the contest, a 75-yard strike from quarterback Damien Fleming to wide receiver Travis Harvey.
On the next possession, however, Jones came back to find true freshman wide out Trey Metoyer for his first career touchdown catch when the two connected 18-yards to cap off an 11-play, 87-yard drive and lead 35-10 into the half.
"I mean, Trey showed what he can do," Jones said. "You know, he's a big, physical guy, can get down the field."
Just 2:49 into the second half, backup running back Brennan Clay got in on the action, bursting for a career-long 18-yard run then finishing off the drive with a 3-yard touchdown run.
Then, it was Williams' time once again.
He blasted upfield for the program's seventh-longest touchdown run, an 89-yarder that put OU up 49-10 at the time.
"Anybody could have ran through that hole with the line blocking the way they were," Williams said. "[Fullback] Trey Millard made a good block on the safety, so anybody could have done it. I had to turn my speed up to finish through, but it went as planned."
Clay got on the scoreboard for his second time on the next Sooner possession, splitting the defense on a stretch play to the right to make it 56-10.
Starting running back Dominique Whaley became the third Sooner back to score a touchdown when he raced in from 4-yards out early in the fourth quarter.
Running back Roy Finch became the fourth when he capped off the Sooner scoring with a 15-yard score with 5:59 remaining.
"Like I've been saying over and over, teams are going to have to look out for us [running backs]," Williams said. "We just have to keep progressing, keep running the ball hard and taking care of it."
While the four backs combined for eight scores, Jones finished 19-of-28 for 252 yards and two touchdowns, despite throwing a pick.
Stills led all receivers with 120 yards on 10 catches, becoming the 11th Sooner player all-time to catch double-digit passes.
"Ultimately, we did some positive things, had some yards, scored some points," said co-offensive coordinator and play caller Josh Heupel. "But there are a lot of things out there that we need to clean up to be as efficient as we are capable of."
For FAMU, Fleming was 11-of-21 for 133 yards and a touchdown, while also throwing a pick.
Harvey had four catches for 118 yards and a touchdown.
The Sooners now have their aforementioned bye week before taking on Kansas State Sept. 22 at home.